Deep Blue Mind Enhancing Blend

Sabaratnam V, Kah-Hui W, Naidu M, Rosie David P. Neuronal health – can culinary and medicinal mushrooms help?. J Tradit Complement Med. 2013;3(1):62-68. doi: 10.4103/2225-4110.106549

Lai, Puei-Lene; Naidu, Murali; Sabaratnam, Vikineswary; Wong, Kah-Hui; David, Rosie Pamela; Kuppusamy, Umah Rani; Abdullah, Noorlidah; Malek, Sri Nurestri A. Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int J Med Mushrooms ; 15(6): 539-54, 2013. DOI: 10.1615/intjmedmushr.v15.i6.30

Tuli HS, Sandhu SS, Sharma AK. Pharmacological and therapeutic potential of Cordyceps with special reference to Cordycepin. 3 Biotech. 2014;4(1):1‐12. doi: 10.1007/s13205-013-0121-9

Panda AK, Swain KC. Traditional uses and medicinal potential of Cordyceps sinensis of Sikkim. J Ayurveda Integr Med. 2011;2(1):9‐13. doi: 10.4103/0975-9476.78183

Wachtel-Galor S, Yuen J, Buswell JA, et al. Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 9. Available from: https://www.ncbi.nlm.nih.gov/books/NBK92757/

NeuroFactor® & DHH-B

Reyes-Izquierdo, T., Nemzer, B., Shu, C., Huynh, L., Argumedo, R., Keller, R., & Pietrzkowski, Z. (2013). Modulatory effect of coffee fruit extract on plasma levels of brain-derived neurotrophic factor in healthy subjects. British Journal of Nutrition, 110(3), 420-425. doi:10.1017/S0007114512005338

Mullen, W., Nemzer, B., Ou, B., Stalmach, A., Hunter, J., Clifford, M. N., & Combet, E. (2011). The Antioxidant and Chlorogenic Acid Profiles of Whole Coffee Fruits Are Influenced by the Extraction Procedures. Journal of Agricultural and Food Chemistry, 59(8), 3754–3762. DOI: 10.1021/jf200122m

Duangjai, A., Suphrom, N., Wungrath, J., Ontawong, A., Nuengchamnong, N., & Yosboonruang, A. (2016). Comparison of antioxidant, antimicrobial activities and chemical profiles of three coffee (Coffea arabica L.) pulp aqueous extracts. Integrative Medicine Research, 5(4), 324–331. DOI: 10.1016/j.imr.2016.09.001

Bekinschtein P, Cammarota M, Katche C, et al. BDNF is essential to promote persistence of long-term memory storage. Proceedings of the National Academy of Sciences of the United States of America. 2008;105(7):2711-2716. doi:10.1073/pnas.0711863105.

Woodbury A, Yu SP, Wei L, García P. Neuro-modulating effects of honokiol: a review. Front Neurol. 2013;4:130. Published 2013 Sep 11. doi: 10.3389/fneur.2013.00130

GABA (Gamma-Aminobutyric Acid)

Lakhan SE, Vieira KF. Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review. Nutr J. 2010;9:42. Published 2010 Oct 7. doi: 10.1186/1475-2891-9-42

Spiering MJ. The discovery of GABA in the brain. J Biol Chem. 2018;293(49):19159‐19160. doi: 10.1074/jbc.CL118.006591

Belloni L, Savioli F, Barbieri C. [On the antihypertensive properties of gamma-aminobutyric acid. Clinical experience in 29 hypertensive patients] Archivio "E. Maragliano" di Patologia e Clinica. 1966 Feb;22(1):119-145.

H. Nakamura, T. Takishima, T. Kometani & H. Yokogoshi (2009) Psychological stress-reducing effect of chocolate enriched with γ-aminobutyric acid (GABA) in humans: assessment of stress using heart rate variability and salivary chromogranin A, International Journal of Food Sciences and Nutrition, 60:sup5, 106-113, DOI: 10.1080/09637480802558508

Abdou, Adham & Higashiguchi, S & Horie, K & Kim, Mujo & Hatta, Hajime & Yokogoshi, H. (2006). Relaxation and immunity enhancement effects of γ-Aminobutyric acid (GABA) administration in humans. BioFactors (Oxford, England). 26. 201-8. DOI: 10.1002/biof.5520260305.

Organic Alaskan Blueberries

Dinstel RR, Cascio J, Koukel S. The antioxidant level of Alaska's wild berries: high, higher and highest. Int J Circumpolar Health. 2013;72:10.3402/ijch.v72i0.21188. Published 2013 Aug 5. doi: 10.3402/ijch.v72i0.21188

Mary H. Grace, Debora Esposito, Kriya L. Dunlap, and Mary Ann Lila. Comparative Analysis of Phenolic Content and Profile, Antioxidant Capacity, and Anti-inflammatory Bioactivity in Wild Alaskan and Commercial Vaccinium Berries. Journal of Agricultural and Food Chemistry 2014 62 (18), 4007-4017. DOI: 10.1021/jf403810y

Dróżdż, P., Šėžienė, V. & Pyrzynska, K. Phytochemical Properties and Antioxidant Activities of Extracts from Wild Blueberries and Lingonberries. Plant Foods Hum Nutr 72, 360–364 (2017). DOI: 10.1007/s11130-017-0640-3

Ashwagandha

Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of Ashwagandha root in reducing stress and anxiety in adults. Indian Journal of Psychological Medicine, 34(3), 255–262. doi: 10.4103/0253-7176.106022

Björnsson, HK, Björnsson, ES, Avula, B, et al. Ashwagandha‐induced liver injury: A case series from Iceland and the US Drug‐Induced Liver Injury Network. Liver Int. 2020; 40: 825– 829. https://doi.org/10.1111/liv.14393

Shah, N., Singh, R., Sarangi, U., Saxena, N., Chaudhary, A., Kaur, G., Kaul, S. C., & Wadhwa, R. (2015). Combinations of Ashwagandha leaf extracts protect brain-derived cells against oxidative stress and induce differentiation. PloS one, 10(3), e0120554. DOI: 10.1371/journal.pone.0120554

Wadhwa, R., Singh, R., Gao, R., Shah, N., Widodo, N., Nakamoto, T., Ishida, Y., Terao, K., & Kaul, S. C. (2013). Water extract of Ashwagandha leaves has anticancer activity: identification of an active component and its mechanism of action. PloS one, 8(10), e77189. DOI: 10.1371/journal.pone.0077189

Kaur, K., Rani, G., Widodo, N., Nagpal, A., Taira, K., Kaul, S. C., & Wadhwa, R. (2004). Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 42(12), 2015–2020. DOI: 10.1016/j.fct.2004.07.015

Salve, J., Pate, S., Debnath, K., & Langade, D. (2019). Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study. Cureus, 11(12), e6466. DOI: 10.7759/cureus.6466Lopresti, A. L., Smith, S. J., Malvi, H., & Kodgule, R. (2019). An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine, 98(37), e17186. DOI: 10.1097/MD.0000000000017186

Langade, D., Kanchi, S., Salve, J., Debnath, K., & Ambegaokar, D. (2019). Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study. Cureus, 11(9), e5797. DOI: 10.7759/cureus.5797

Kelgane, S. B., Salve, J., Sampara, P., & Debnath, K. (2020). Efficacy and Tolerability of Ashwagandha Root Extract in the Elderly for Improvement of General Well-being and Sleep: A Prospective, Randomized, Double-blind, Placebo-controlled Study. Cureus, 12(2), e7083. DOI: 10.7759/cureus.7083

Ven Murthy, M. R., Ranjekar, P. K., Ramassamy, C., & Deshpande, M. (2010). Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: ashwagandha. Central nervous system agents in medicinal chemistry, 10(3), 238–246. DOI: 10.2174/1871524911006030238

 Pratte, M. A., Nanavati, K. B., Young, V., & Morley, C. P. (2014). An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). Journal of alternative and complementary medicine (New York, N.Y.), 20(12), 901–908. DOI: 10.1089/acm.2014.0177

Singh, R., Gupta, P., Khan, F., Singh, S. K., Sanchita, Mishra, T., Kumar, A., Dhawan, S. S., & Shirke, P. A. (2018). Modulations in primary and secondary metabolic pathways and adjustment in physiological behaviour of Withania somnifera under drought stress. Plant science : an international journal of experimental plant biology, 272, 42–54. DOI: 10.1016/j.plantsci.2018.03.029